Fig. 4: Global phosphoproteomic analysis of the MT/YH and SAMT/SAYH cells: interactions of proteins corresponding to the differentially expressed peptides and their enrichments.
From: A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response
A A joint comparison of unchallenged MT vs. SAMT and YH vs. SAYH cells. B SAMT and SAYH response to irradiation (controls vs. irradiated samples, 1 h after 10 Gy). C SAMT and SAYH response to irradiation (controls vs. irradiated samples, 7 h after 10 Gy). D A joint comparison of MT vs. SAMT and YH vs. SAYH (both 1 h and 7 h after 10 Gy). Colors indicate the proteins’ affiliation enriched biological processes specified in the legend. We use the FDR thresholds 0.50 in A and 0.25 in B–D. E The enrichment significance of reactome pathways for various irradiation-involving comparisons. Cell cycle emerges here as the only pathway that is significantly enriched for all comparisons involving SAMT and SAYH cell lines.
