Table 3 Ongoing clinical trials on cancer-associated circRNAs as biomarkers or therapeutic targets (https://clinicaltrials.gov/).
From: Going circular: history, present, and future of circRNAs in cancer
Study title | Condition or disease | Intervention/treatment | Country of the study | Status of the study |
|---|---|---|---|---|
CIRcular and Non-coding RNAs as Clinically USeful Biomarkers in Pancreaticobiliary Cancers (CIRCUS) (NCT04584996) | • Pancreatic Cancer • Biliary Tract Cancer |  | United Kingdom | Recruiting |
A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma (NCT03334708) | • Pancreatic Cancer • Pancreatic Diseases • Pancreatitis • Pancreatic Cyst | • Diagnostic Test: Blood Draw • Diagnostic Test: Tumor Tissue Collection • Diagnostic Test: Cyst Fluid | United States (5 hospitals involved) | Recruiting |
Thyroid Nodule Gene Sequencing in a Danish Population (NCT05377736) | • Thyroid Nodule • (Diagnosis) Thyroid Cancer | • Genetic: Molecular analyses | Denmark | Enrolling by invitation |
Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN) (NCT04464122) | • Neuroendocrine Tumors • Neuroendocrine Neoplasm • Neuroendocrine Tumor Grade 1 • Neuroendocrine Tumor Grade 2 • Neuroendocrine Carcinoma | • Drug: Somatostatin analog; Chemotherapy | Italy | Recruiting |
Research on Precise Immune Prevention and Treatment of Glioma Based on Multi-omics Sequencing Data (NCT04792437) | • Transcriptomics • Radiomics • Glioma | • Procedure: Surgery | China | Recruiting |
Gene Therapy and Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma (NCT02337985) | • AIDS-Related Burkitt Lymphoma • AIDS-Related Diffuse Large B-cell Lymphoma • AIDS-Related Plasmablastic Lymphoma • AIDS-Related Primary Effusion Lymphoma • HIV Infection • AIDS-Related Non-Hodgkin Lymphoma | • Drug: Prednisone • Biological: Rituximab • Drug: Etoposide • Drug: Doxorubicin Hydrochloride • Drug: Vincristine Sulfate • Drug: Cyclophosphamide • Biological: Filgrastim • Biological: Lentivirus Vector rHIV7-shI-TAR-CCR5RZ-transduced Hematopoietic Stem/Progenitor Cells | United States | Active, not recruiting |
