Fig. 7: JMJD6 knockdown enhances PD-1-sensitivity in mice. | Oncogene

Fig. 7: JMJD6 knockdown enhances PD-1-sensitivity in mice.

From: JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis

Fig. 7: JMJD6 knockdown enhances PD-1-sensitivity in mice.

a Schematic diagram of anti-PD-1 treatment on WT and Jmjd6+/− mice B16F10 lung metastasis tumor model. b Lung photo at the end of the experiment. c Statistical results of the number of lung tumor nodules in mice. d Representative images of mouse lungs H&E staining. e The infiltration of M2-like TAMs (CD206+ MHC-II-), detected by flow cytometry. f The infiltration of CD3+ total T cells, detected by flow cytometry. g The infiltration of CD8+ GZMB+ T cells, detected by flow cytometry. h Illustration of mechanism for JMJD6/STAT3/IL-10 axis. Data represent mean ± SD (n = 5). ns: no significant difference, *P < 0.05, **P < 0.01, ***P < 0.001.

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