Fig. 1: The absence of BCL-W does not markedly impact the survival of Eµ-Myc transgenic mice.

A–C Kaplan-Meier survival curves representing the tumour-free survival of all Eµ-Myc^T/+;Bcl-w^+/+, Eµ-Myc^T/+;Bcl-w^+/−, or Eµ-Myc^T/+;Bcl-w^−/− mice (A), or stratified by gender (B, C). No significant differences, regardless of gender stratification, were observed when comparing Eµ-Myc^T/+;Bcl-w^+/+ animals to either Eµ-Myc^T/+;Bcl-w^+/− or Eµ-Myc^T/+;Bcl-w^−/− animals (Mantel-Cox tests with Bonferonni’s multiple comparisons (K = 2), adjusted p > 0.025). D–F Quantification of blood cell types in moribund Eµ-Myc^T/+;Bcl-w^+/+, Eµ-Myc^T/+;Bcl-w^+/−, and Eµ-Myc^T/+;Bcl-w^−/− mice. No significant differences were observed between the genotypes for either white blood cells (D), red blood cells (E), or platelets (F). G–I Quantification of organ weights from sick Eµ-Myc^T/+;Bcl-w^+/+, Eµ-Myc^T/+;Bcl-w^+/−, and Eµ-Myc^T/+;Bcl-w^−/− mice at ethical endpoint. No significant differences were observed between the genotypes for either the lymph nodes (G), spleen (H), or thymus (I). In each graph, the dotted line represents the average result for that parameter from healthy C57BL/6 mice.