Fig. 1: ‘Inside-out’ (serosa-to-mucosa) regression pattern of response seen in patients with colon and rectal cancer receiving botensilimab plus balstilimab in the neoadjuvant setting. | Oncogene

Fig. 1: ‘Inside-out’ (serosa-to-mucosa) regression pattern of response seen in patients with colon and rectal cancer receiving botensilimab plus balstilimab in the neoadjuvant setting.

From: Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer

Fig. 1

As shown, compared to traditional responses seen with chemotherapy, targeted therapy and/or radiation, the residual proportion of the tumor cells are all confined to the luminal surface with immunotherapy. This can be best described as a wave or tsunami of immune cells infiltration and subsequent cancer cell death.

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