Fig. 3: IGF2BP3 promotes cancer stemness of NPC. | Oncogene

Fig. 3: IGF2BP3 promotes cancer stemness of NPC.

From: The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma

Fig. 3

A Representative images of the tumor spheres formed in the indicated HONE1 and SUNE1 cells. Scale bars: 200 µm. B Representative images (left) and quantification (right) of the side-population cells in the indicated HONE1 and SUNE1 cells. C Western blotting analyses of the stemness markers (NANOG, OCT4, and CD44) in the indicated HONE1 and SUNE1 cells. GAPDH was used as the loading control. D Tumor volume curves of the different groups. E Frequency of tumor-initiating cells in the different groups analyzed using ELDA software (http://bioinf.wehi.edu.au/software/elda/). F Tumor weigh (left) and representative images of tumors (right) of the indicated groups. Each error bar in (B) represents the mean ± SD of three independent experiments. Each error bar in (D) and (F) represent the mean ± SD of the tumor mouse models (n = 8/group). *P < 0.05; **P < 0.01; ***P < 0.001.

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