Fig. 4: Bortezomib could target to PSMD2. | Oncogene

Fig. 4: Bortezomib could target to PSMD2.

From: Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer

Fig. 4

A The network diagram shows the results of small molecule drug matching, correlation pathway analysis, protein-protein correlation analysis, protein-RNA correlation analysis and family member analysis of PSMD2. B The combination of bortezomib and PSMD2 was detected in H1299 and A549 cells with 14 temperature gradients set between 50 °C and 70 °C by thermal shift assay. Y represents cells were treated with bortezomib for 1 h, and N represents treatment with an equal amount of DMSO for 1 h. C–F Affinity of bortezomib with PSMD2, PSMB1, PSMB2 and PSMB5 were detected by molecular docking.

Back to article page