Fig. 7: Bortezomib targets to proteasome subunit coding genes to inhibit cell proliferation of NSCLC. | Oncogene

Fig. 7: Bortezomib targets to proteasome subunit coding genes to inhibit cell proliferation of NSCLC.

From: Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer

Fig. 7

Under the synergistic effect of USP14, knocking out PSMD2 or treating with bortezomib can inhibit the degradation of proteasomes of p21 and p27, reduce the activity of cyclin/CDK complexes, and block the cell cycle in G0/G1 phase, thereby inhibiting the proliferation of NSCLC.

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