Fig. 4: PTEN controls chemotaxis through PI3K-p110 and AKT isoforms.
From: PTEN-regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression
A The chemotactic abilities of LNCaP vs. LNCaP[PTEN] or T402 vs. T402[PTEN] were assessed using transwell assays with serum added to the lower chamber. The effect of PTEN re-expression, p110 and/or AKT isoform inhibitors on T402 (B) or on LNCaP isogenic pair (C) chemotaxis was assessed, as was the effect of increasing AKT2i on LNCaP (D). ns not significant. *P < 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001.
