Fig. 1: Downregulation of ZFP36L1 is correlated with the malignant progression of osteosarcoma. | Oncogene

Fig. 1: Downregulation of ZFP36L1 is correlated with the malignant progression of osteosarcoma.

From: Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop

Fig. 1: Downregulation of ZFP36L1 is correlated with the malignant progression of osteosarcoma.

A Venn diagram showing that the expression of 7 RBPs significantly differed in GSE85537 (bone lesions vs. lung metastases) and GSE18947 (cells with low metastatic potential vs. cells with high metastatic potential). B q-PCR assays of RBP-encoding genes in cells that migrated or did not migrate in Transwell assays. C Representative IHC images of ZFP36L1, Vimentin and N-cadherin in individual samples from among 70 OS specimens. Scale bar, 100 μm. D The percentage of samples with low or high ZFP36L1 expression compared to the expression of Vimentin and N-cadherin. E Relative expression of ZFP36L1 in samples from individual OS patients with different tumor stages. Bioluminescence images (F) were captured to compare tumor growth in the lungs, and the bioluminescence levels (G) were measured by LivingImage software. H, I Representative HE staining and gross images (H) of lungs in mice injected with 143B cells expressing different levels of ZFP36L1. The number of lung tumors (I) in different groups of mice was counted. Scale bar, 120 μm. The data are shown as means ± SEMs; *P < 0.05, **P < 0.01.

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