Fig. 1: GR mRNA and protein expression in benign and malign prostate tissue. | Oncogene

Fig. 1: GR mRNA and protein expression in benign and malign prostate tissue.

From: Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Fig. 1

A Single-cell RNA-seq from 4 PCa patients and t-SNE analysis of 24.625 cells freshly isolated PCa cells, as well as a violin blot for NR3C1 expression levels in identified and selected cell subpopulations. B Quantification of stromal and epithelial GR immune-reactivity scores (IRS) in benign and malign tissue specimens, including 280 PCa patients after IHC staining for GR (one-way ANOVA and correction for multiple testing using Dunn’s comparison test; ***P < 0.001; Box Whisker Plot with 5–95 percentile). C, D Representative microscopy images of benign and primary PCa tissues and diverse metastatic lesions for stromal and epithelial GR expression. Magnification: ×20 (scale bar = 50 µm) and ×63 (scale bar = 20 µm).

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