Fig. 4: YAP activation induces CD24 expression in ESCC cells. | Oncogene

Fig. 4: YAP activation induces CD24 expression in ESCC cells.

From: The Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis

Fig. 4: YAP activation induces CD24 expression in ESCC cells.The alternative text for this image may have been generated using AI.

A, B Flow cytometry analysis of CD24 cell surface expression in Mock, YAP-5SA, and YAP-5SA-S94A expressing EC9706 and ECA109 cells. C, D Immunofluorescence analysis of CD24 cell surface expression in Mock, YAP-5SA, and YAP-5SA-S94A expressing EC9706 and ECA109 cells. Scale bars, 10 μm. E Immunoblotting analysis shows constitutive YAP activation induced CD24 expression in ESCC cells. F qRT-PCR analysis of CD24 mRNA levels in Mock, YAP-WT, YAP-5SA, and YAP-5SA-S94A expressing EC9706 and ECA109 cells. G Luciferase reporter activity was measured in cells expressing the indicated plasmids. H Blocking YAP activation by VP resulted in lower CD24 expression.

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