Fig. 3: Androgen receptor (AR) is predicted to be an upstream regulator in the lung metastases of OS patients. | Oncogene

Fig. 3: Androgen receptor (AR) is predicted to be an upstream regulator in the lung metastases of OS patients.

From: RNA-sequencing predicts a role of androgen receptor and aldehyde dehydrogenase 1A1 in osteosarcoma lung metastases

Fig. 3

A IPA (Qiagen, v68752261) analysis on all genes (Cut-offs for Exp. Log ratio = −0.58 and 0.58 and FDR = 0.01) revealed genes upregulated in LM compared to extremity tumors were found to be involved in several pathways, including the AR pathway. Several genes downstream of AR (p-value = 4.11 × 10–6) were found to be significantly upregulated in LM tissue, including aldehyde dehydrogenase (ALDH, log2FC = 1.48, FDR = 0.02). B AR and C ALDH expression values (log2normCPMs). FDR calculated by Bejamini-Hochberg adjustment is shown. D AR expression levels across cancer cell subtypes from the Broad Cancer Cell Line Encyclopedia via a waterfall plot based on median expression. OS is outlined in the box.

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