Fig. 5: p27 is required for MET TKI and harmine induced cytotoxicity. | Oncogene

Fig. 5: p27 is required for MET TKI and harmine induced cytotoxicity.

From: TWIST1 is a critical downstream target of the HGF/MET pathway and is required for MET driven acquired resistance in oncogene driven lung cancer

Fig. 5

A Western blot demonstrating partial knockdown of p27. B Western blot demonstrating that capmatinib treatment induces less p27 in shp27 H1993 cells compared to control (Scr) cells. Cell-Titer Glo assay demonstrating that p27 knockdown decreases response to C capmatinib D crizotinib E tepotinib. and F harmine Data represent mean ± SD (n = 4 technical replicates). *P < 0.05, **P < 0.01, ***P < 0.001,****P < 0.0001, two-way ANOVA.

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