Fig. 3: CBP/p300 inhibition drastically reduces the AR, CBP, p300 cistromic landscape.
From: AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer
A ChIP-Seq of intensity plots of 22Rv1 control and CCS1477 treated cells. AR, CBP, and p300 were immunoprecipitated in CCS1477 exclusive, common binding, and VEH exclusive in a 6-kb region. B Percent of total binding of overlap of common bindings sites of AR, CBP, and p300 in CCS treated 22Rv1 cells. C Known motif of AR, CBP, and p300 of common binding in 22Rv1 CCS1477 treated cells. D Motifs of binding regions of AR, CBP, and p300 visualized for top 6 highest p-values. E Hallmarks GSEA pathways regulated by CBP and p300 in CCS1477 treated 22Rv1 cells.
