Fig. 3: Fixation of EWS::FLI1 and EWS::ERG near KCNN1 promoter. | Oncogene

Fig. 3: Fixation of EWS::FLI1 and EWS::ERG near KCNN1 promoter.

From: Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling

Fig. 3

A H3K4me3, H3K27ac and FLI1 ChIP-Seq data with quantitative value of peaks around KCNN1 promoters and sequences of EWS::FLI1 binding sites in A-673 (left panel) and TC106 (right panel) cell lines. B H3K27ac ChIP-Seq of A-673/TR/shEF cell line at day 0 and day 7 of doxycycline treatment with quantitative value of peaks around KCNN1 promoters. C FLI1 ChIP-Seq of A-673/TR/shEF cell line with quantitative value of FLI1 peaks around KCNN1 promoters, at day 7 of doxycycline treatment, and 3 days (day 7 + 3), 4 days (day 7 + 4), 7 days (day 7 + 7) and 10 days (day 7 + 10) after discontinuation of doxycycline treatment. D H3K27ac and FLI1 ChIP-Seq data on MSCs transfected with control plasmid, FLI1 overexpression plasmid or EWS::FLI1 overexpression plasmid around KCNN1 promoters.

Back to article page