Fig. 3: Dex and SUMOi regulate expression of gene subsets in a potentiating manner. | Oncogene

Fig. 3: Dex and SUMOi regulate expression of gene subsets in a potentiating manner.

From: SUMOylation inhibition potentiates the glucocorticoid receptor to program growth arrest of acute lymphoblastic leukemia cells

Fig. 3

A Clustering of differentially expressed genes (DEGs) according to Dex vs CTRL and Dex+SUMOi vs Dex effects. Heatmaps of genes in indicated example pathways from DEG clusters Dex-up/SUMOi-up (B) and Dex-dn/SUMOi-dn (C). D DAVID pathway analyses of DEG clusters presented in A; numbers in parentheses indicate number of genes in pathway. Dashed line indicates āˆ’log10 transformation of significance threshold (p-valueā€‰<ā€‰0.05).

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