Fig. 6: Methylation changes at gene promoters. | Oncogene

Fig. 6: Methylation changes at gene promoters.

From: Comprehensive metabolomic and epigenomic characterization of microsatellite stable BRAF-mutated colorectal cancer

Fig. 6: Methylation changes at gene promoters.

A Gene set enrichment analysis of genes with >6 hyper-DMLs at their promoters in MSS BRAF V600E tumors. Results are sorted by FDR. B Pooled methylation levels across AQP5 gene from 7 normal samples, 6 MSS BRAF V600E and 26 MSS WT samples. C Pooled methylation levels at the promoter of MLH1 from 7 normal samples, 4 MSI samples (dashed lines, 2 BRAF V600E + 2 WT), and 32 MSS samples (solid lines, 6 BRAF V600E, 26 WT). MLH1 promoter methylation is low in MSS BRAF V600E tumors. This, together with our observation that MAFG is not highlighted by the TF methylation analysis, suggests that a mechanism other than increased MAFG activity is likely to explain the overall hypermethylation pattern in MSS BRAF-mutated CRCs.

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