Table 1 Examples of reported BC dormancy models used to study various dormancy survival mechanisms.
From: Decoding the adaptive survival mechanisms of breast cancer dormancy
Mode of dormancy induction | Model type | Described survival mechanism |
|---|---|---|
Therapy induced (5-azacytidine and retinoic acid) | in vitro (2D) | Transcriptional reprogramming [101] |
Therapy induced (aromatase inhibitor-mimicking) | in vivo (mouse) | Metabolic and Transcriptional reprogramming, Autophagy [96] |
Therapy induced (tamoxifen) | in vitro (2D) | |
Hypoxia | in vitro (2D) | |
Hypoxia | in vivo (mouse) | Transcriptional reprogramming [17] |
Extracellular matrix interactions | in vitro (3D) | Transcriptional reprogramming [191] |
Extracellular matrix interactions (metastatic niche) | in vitro (2D) & in vivo (mouse & zebrafish) | Transcriptional reprogramming [192] |
Extracellular matrix interaction | in vitro (2D) & in vivo (mouse & chicken eggs) | Transcriptional reprogramming [60] |
Extracellular matrix interaction | in vitro (3D) & In vivo (mouse) | Transcriptional reprogramming [193] |
Metastatic niche (bone marrow) | in vitro (co-culture, 2D) & in vivo (mouse) | Autophagy [194] |
Metastatic niche (lungs) | in vivo (mouse) | Immune evasion and Cytokine signalling [195] |
