Fig. 1: Association between GABA pathway gene expression and patient outcomes in the CALGB/SWOG 80405 trial. | Oncogene

Fig. 1: Association between GABA pathway gene expression and patient outcomes in the CALGB/SWOG 80405 trial.

From: GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancer

Fig. 1

Forest plots show the association of GAD1 tumor expression as a continuous variable with PFS (A) and OS (B) across treatment arms; Forest plots show the association of ABAT tumor expression with PFS (C) and OS (D) across treatment arms. Kaplan-Meier curves show PFS (E) and OS (F) stratified by GAD1 tumor expression tertiles (T1 low, T2 middle, and T3 high) in the overall population of the CALGB/SWOG 80405 trial. The statistical comparison is performed for T3 vs T1. Kaplan-Meier curves show PFS (G) and OS (H) stratified by ABAT tumor expression tertiles in the overall population of the CALGB/SWOG 80405 trial. The statistical comparison is performed for T3 vs T1. P values are based on log-rank test for PFS and OS in the univariate categorical analysis, and likelihood ratio test in the univariate continuous and multivariable Cox proportional hazards regression model. bev bevacizumab, cet cetuximab, CI confidence interval, HR hazard ratio, OS overall survival, PFS progression-free survival.

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