Fig. 3: Tumor-derived GABA is increased in Ras altered tumors. | Oncogene

Fig. 3: Tumor-derived GABA is increased in Ras altered tumors.

From: GABAergic signaling contributes to tumor cell invasion and poor overall survival in colorectal cancer

Fig. 3

A Tumor characteristics and patient demographics. B Representative 10x immunofluorescence images of the 6 tumors stained for EpCAM (green), CK20 (red), and GABA (purple). Scale bars represent 500 μm for all tumors except for UK at 200 μm, due to the different tissue sizes. C GABA intensity quantification of N = 10 regions that were CK20+ tumor areas/patient. D Average GABA intensity grouped by Ras signaling. N = 3 patients/grouping; **P = 0.0057. Data was analyzed using an unpaired t-test. All data are shown as mean ± SEM. All schematics were made in or are from BioRender.

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