Fig. 1: Inhibition of SREBP-dependent lipogenesis decreases levels of total cellular lipids and lipid saturation. | Oncogene

Fig. 1: Inhibition of SREBP-dependent lipogenesis decreases levels of total cellular lipids and lipid saturation.

From: Targeting SREBP-dependent lipogenesis potentiates the anti-tumor activity of docetaxel by increasing membrane permeability and intracellular drug accumulation

Fig. 1

A Bar graph showing the relative MS1 peak area intensity of all identifiable lipids in C4-2 or PC3 cells treated with 1 nM docetaxel in the absence or presence of 5 μM FGH10019 for 48 h. B−E A statistically significant alteration in abundance of various lipid classes (B, C) or fatty acyl chains (D, E) in C4-2 (B, D) or PC3 (C, E) cells treated with 1 nM docetaxel in the absence or presence of 5 μM FGH10019 for 48 h. MS1 peak area represents the relative quantification of the intensity of identified lipids across the sample set. CerG1 simple Glc series 1, CerG2 simple Glc series 2, PS phosphatidylserine, LPG lysophosphatidylglycerol, TG triglyceride, MePC monoetherphosphatidylcholin, DG diglyceride, LPI lysophosphatidylinositol, LPS lysophosphatidylserine, MG monoglyceride, So sphingosine, CL cardiolipin. Unpaired two-tailed t test was used to determine significance. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. All data are mean ± s.d. from n = 3 biological replicates.

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