Fig. 4: PAK signaling contributes to the spontaneous BRAFi resistance of the A375 VRPP cell lines. | Oncogene

Fig. 4: PAK signaling contributes to the spontaneous BRAFi resistance of the A375 VRPP cell lines.

From: A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition

Fig. 4: PAK signaling contributes to the spontaneous BRAFi resistance of the A375 VRPP cell lines.

A375 VRPP1, VRPP2, and VRPP3 cell lines were grown in the presence of DMSO vehicle (CON), 3 µM vemurafenib (VEM), 1 µM G-5555 (G5), or 3 µM vemurafenib plus 1 µM G-5555 (VEM/G5), and fold change in cell growth was measured over time via resazurin assay. Co-treatment with G-5555 reduced the resistance of the VRPP cell lines to vemurafenib. See Supplementary Table S2 for area under the curve (AUC) statistical analysis of differences in growth curves compared to DMSO control.

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