Fig. 1: Spatial transcriptomic profiling and single-cell analysis of primary MCC lesions exhibiting epidermotropism. | Oncogene

Fig. 1: Spatial transcriptomic profiling and single-cell analysis of primary MCC lesions exhibiting epidermotropism.

From: High-resolution spatial transcriptomics uncover epidermal-dermal divergences in Merkel cell carcinoma: spatial context reshapes the gene expression landscape

Fig. 1

A Immunohistochemistry staining for Cytokeratin 20 in sample #2 in 20× magnification with 1 mm scale bar at the bottom right. High power fields (200×, i and ii) highlights epidermotropic MCC cells forming intraepidermal nests, as indicated by arrows, 100 μm scale bars are shown at the bottom right. B UMAP dimensionality reduction of segmented single-cell data inferred from spatial transcriptomic data, colors represent distinct transcriptional clusters. C Spatial mapping of segmented single-cell data with cells color-coded as defined in (B). D Normalized expression of representative gene markers in histomorphologically annotated cell populations: epiMCC epidermal MCC, cMCC tumor core MCC, vasMCC perivascular MCC, bK basal keratinocytes, and sbK suprabasal keratinocytes.

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