Fig. 4: Genome-wide binding profile of FRA1 in melanoma.
From: FRA1 drives melanoma metastasis through an actionable transcriptional network
A A375 and 1205Lu cells were subjected to Cut&Run sequencing by FRA1 and IgG as negative control. Heatmap showing the read density of FRA1 on the genomes of A375 cells and 1205Lu cells. Venn diagram showing the overlapped peaks. B De Novo Motif analysis by HOMER showing enriched motifs of FRA1 in melanoma cells. C Genomic annotation of overlapped FRA1 bound peaks in A375 and 1205Lu cells. D Scatter plot showing the enrichment of overlapping FRA1 peaks in A375 cells and 1205Lu cells. E, F Gene Ontology (GO) analysis of overlapping FRA1 peaks showing the enriched gene signature in GO Biological Process (E) and GO Molecular Function (F).
