Fig. 1: Characterization of lncRNA1456 and its encoded peptide, XCP. | Oncogene

Fig. 1: Characterization of lncRNA1456 and its encoded peptide, XCP.

From: X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer

Fig. 1: Characterization of lncRNA1456 and its encoded peptide, XCP.

A Genome browser view for the lncRNA1456 locus from fractionated RNA-seq data (cytoplasm vs nuclear) in the presence or absence of estrogen (E2) [19]. B Evolutionary Conserved Regions (ECR) browser tracks showing conservation of lncRNA1456 locus across different species. C Diagram showing the putative lncRNA1456-encoded peptide (XCP) from exons 1 and 2 and amino acid sequence. D Coomassie gel showing recombinant XCP peptide (left) and its endogenous detection in MCF-7 cells by Western blot using a derived XCP antibody (right). E Western blot showing reduced levels of endogenous XCP peptide upon siRNA-mediated knockdown of lncRNA1456 RNA in MCF-7 cells. β-tubulin was used a loading control. [See also Fig. S1].

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