Fig. 4: XCP modulates gene expression and regulates cellular pathways in a context-dependent manner. | Oncogene

Fig. 4: XCP modulates gene expression and regulates cellular pathways in a context-dependent manner.

From: X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer

Fig. 4: XCP modulates gene expression and regulates cellular pathways in a context-dependent manner.

A,B Heatmaps (left) and Gene Ontology analysis (right) showing XCP-mediated gene expression changes in MCF-7 (A) and MDA-MB-231 (B) xenograft tumors. C,D Box plots showing gene set analysis of XCP-induced genes and their expression levels stratified into breast cancer subtypes using PAM50 gene set analysis (left) and stratified by ER status (right) in MCF-7 (C) and MDA-MB-231 (D) xenograft tumors. Observed differences are significant as determined by an ANOVA comparison of the means (P value < 0.00001). [See also Fig. S3].

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