Fig. 1: KDM4B is highly expressed in chemoresistant cells and tissues of SCLC. | Oncogene

Fig. 1: KDM4B is highly expressed in chemoresistant cells and tissues of SCLC.

From: KDM4B/DHX9 promotes chemoresistance in small-cell lung cancer through the MYCN-driven signaling pathway

Fig. 1: KDM4B is highly expressed in chemoresistant cells and tissues of SCLC.The alternative text for this image may have been generated using AI.

A Phylogenetic tree of histone demethylation proteins, illustrating the similarities between different proteins. B The forest plot summarizes the summary results of genes highly expressed in chemoresistant cells across 6 pairs of cells. C The forest plot shows linear regression analysis results of KDM4B expression in 6 cell pairs, along with summary estimates derived from a random effects model. RE Model, random effects model; OR, odds ratio. D, E qPCR results showing the expression levels of KDM4A and KDM4B in 9 pairs of chemosensitive and corresponding chemoresistant SCLC cell lines. F, G Immunoblot analyses demonstrating KDM4B protein expression in 9 pairs of chemosensitive and corresponding chemoresistant SCLC cell lines. S, Sensitive; R, Resistant. H Representative IHC staining of KDM4B in SCLC tissues, with statistical quantification presented. ***, p < 0.001; **, p < 0.01; *, p < 0.05.

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