Fig. 2: KDM4B is highly expressed in SCLC and is associated with shorter overall survival. | Oncogene

Fig. 2: KDM4B is highly expressed in SCLC and is associated with shorter overall survival.

From: KDM4B/DHX9 promotes chemoresistance in small-cell lung cancer through the MYCN-driven signaling pathway

Fig. 2: KDM4B is highly expressed in SCLC and is associated with shorter overall survival.The alternative text for this image may have been generated using AI.

A Schematic illustration of the domain structure of the KDM4 family. B Gene expression of KDM4B in paired SCLC and normal lung tissues from the GSE149507 and GSE60052 datasets. C KDM4B gene expression in paired normal and tumor tissue from the TU-SCLC cohort. D KDM4B protein expression in paired normal and tumor tissue from the TU-SCLC cohort. E Gene expression of KDM4B across normal lung tissues and various lung cancer subtypes in the GSE30219 dataset. NTL non-tumoral lung, ADC adenocarcinoma, SQC squamous cell carcinoma, LCNE large cell neuroendocrine tumors, SCLC small cell lung cancer. F, G Univariate Cox regression analysis results showing the associations between KDM4B gene and protein expression and overall survival in SCLC patients. H, I Multivariate Cox regression analysis results incorporating KDM4B gene or protein expression together with clinical factors, including sex, smoking, TNM stage, pleural invasion, vascular invasion, and neural invasion. ***, p < 0. 001; **, p < 0. 01; *, p < 0. 05.

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