Fig. 6: LINC00152 exerts tumor-promoting function in CRC by regulating the miR-139-5p/NOTCH1 axis | Oncogenesis

Fig. 6: LINC00152 exerts tumor-promoting function in CRC by regulating the miR-139-5p/NOTCH1 axis

From: Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p

Fig. 6

a The increased cell viability in pWPXL-LINC00152 transfected CRC cells was abolished by ectopic miR-139-5p expression or NOTCH1 knockdown. The cell viability was measured by a CCK-8 assay. b Increased 5-FU resistance in pWPXL-LINC00152 transfected CRC cells was abolished by ectopic miR-139-5p expression or NOTCH1 knockdown. The IC50s for group (1) to (8) were 0.632, 1.180, 0.327, 0.512, 0.564, 1.014, 0.329, and 0.466 μg/ml, respectively. c Overexpression of LINC00152 decreased 5-FU-induced apoptosis, which was partly blocked by ectopic miR-139-5p expression or NOTCH1 knockdown. d Ectopic miR-139-5p expression or NOTCH1 knockdown could partly block LINC00152-induced cell migration. * or #P < 0.05; **or ##or &&P < 0.01 (* or **: (1) vs. (2) or (5) vs. (6); # or ##: (1) vs. (3) or (5) vs. (7); &&: (1) vs. (4))

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