Fig. 6: FRA1 as regulator of FGF1.
From: BRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1
a Real-time PCR of FOSL1 in indicated melanoma cell lines after three days of vemurafenib treatment. Data are derived from two independent experiments and are referred to control cells treated with the solvent DMSO. b Real-time PCR of FOSL1, MMP2, a FGF1, CCL2 and FGF7 in UACC-62 cells after siRNA-mediated knockdown of FOSL1 for 3 days, using smartpool siRNA. Data are derived from three different experiments. Significant differences are calculated between knockdown and the corresponding control siRNA experiment. c RNASeq results from melan-a FOSL1 cells, expressing doxycycline (Dox)-inducible FOSL1 in response to Dox (1 µg/ml) for 3 and 16 days. Data are derived from34 (GEO accession number GSE85086). d Schematic overview of the FGF1-driven BRAF inhibitor resilience
