Fig. 7: Schematic diagram of cell signaling pathway regulated by MUC15.

Over-expression of MUC15 activate MEK-ERK pathway dependent on integrin-FAK and GPCR-cAMP pathway thereby promote cancer stemness and metastasis. Interestingly, cAMP signaling affects ERK activation independent on Raf-MEK signaling pathway driven by MUC15 over-expression