Fig. 7: Schematic diagram depicting the role of TREM2 in HCC progression and metastasis.

Loss of TREM2 in HCC tumor tissues was regulated by miR-31-5p. TREM2 could interact with β-catenin. Moreover, TREM2 inhibited the phosphorylation of Akt and GSK-3β, thus suppressing β-catenin accumulation in the cytosol and translocation to the nucleus