Fig. 4: miR-214-3p inhibits proliferation, migration, and invasion of non-small-cell lung cancer (NSCLC) cells by targeting fibroblast growth factor receptor 1 (FGFR1).
From: Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer
H1581, DMS114, and HCC95 cell lines were transfected with miR-214-3p-mimic or miR-NC or co-transfection of miR-214-3p-mimic and FGFR1 overexpression plasmid or co-transfection of miR-NC and FGFR1 overexpression plasmid. R1 in the figure represented FGFR1 overexpression plasmid. a, b Cell growth was measured by the CCK8 assay and colony assay. c Transwell assay was conducted to quantify the migration and invasion. d Quantification of epithelial–mesenchymal transition (EMT) markers was measured by western blot. P values were calculated by Student’s t test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001
