Table 1 The abnormal expression of a part of the genome in FaDuCR cells compared with that in FaDu cells

From: Aberrant HER3 ligand heregulin-expressing head and neck squamous cell carcinoma is resistant to anti-EGFR antibody cetuximab, but not second-generation EGFR-TKI

Groups

Gene symbol

Description

Fold change

10 most downregulated genes

KRT4

Keratin 4, type II

−46.17

 

SLPI

Secretory leukocyte peptidase inhibitor

−34.45

 

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

−31.87

 

KRT13

Keratin 13, type I

−29.71

 

FOS

FBJ murine osteosarcoma viral oncogene homolog

−29.58

 

SNORD91B

Small nucleolar RNA, C/D box 91B

−28

 

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

−24.05

 

SNORD14D

Small nucleolar RNA, C/D box 14D

−16.61

 

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

−16.59

 

EGR3

Early growth response 3

−16.12

10 most upregulated genes

PHLDA1

Pleckstrin homology-like domain, family A, member 1

11.9

 

EDIL3

EGF-like repeats and discoidin I-like domains 3

13.1

 

CDH13

Cadherin 13

14.26

 

NT5E

5-nucleotidase, ecto (CD73)

14.59

 

NRG1

Neuregulin 1

17.49

 

FST

Follistatin

23.35

 

KIAA1644

KIAA1644

27.67

 

FHL1

Four and a half LIM domains 1

28.09

 

CCND2

Cyclin D2

28.52

 

DUSP4

Dual specificity phosphatase 4

41.23