Fig. 7: Disruption of Cdc37 leads to BTZ resistance in vivo. | Oncogenesis

Fig. 7: Disruption of Cdc37 leads to BTZ resistance in vivo.

From: Cdc37 suppression induces plasma cell immaturation and bortezomib resistance in multiple myeloma via Xbp1s

Fig. 7: Disruption of Cdc37 leads to BTZ resistance in vivo.

a The schematic diagram of the 5T33MMvt-KaLwRij model. b Kaplan–Meier analyses of overall survival of different experimental groups. c The concentrations of Ig light-chain proteins in the serum of different groups were determined with ELISA (*p < 0.05, **p < 0.01, ***p < 0.001). d B220+CD138+IgM+ plasmablast cells from mice bone marrow were selected with flow cytometry, and the percentages of plasmablast cells were calculated in the respective groups (*p < 0.05, **p < 0.01, ***p < 0.001). e Extramedullary myeloma tissues removed from 5T33MMvt-KaLwRij mice were subjected to immunostaining for CD138 (green) and Xbp1s (orange). f The model of our hypothesis in this work.

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