Fig. 1 : Alterations of MME expression in prostate adenocarcinoma of PtenPE−/− mice. | Oncogenesis

Fig. 1 : Alterations of MME expression in prostate adenocarcinoma of PtenPE−/− mice.

From: Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells

Fig. 1

MME expression in the proximal and distal regions of prostatic ducts of wild-type (WT) and PtenPE−/− 12-month-old mice, non-castrated and castrated at 5 months of age. Arrows indicate areas shown insets. Note that areas of stromal invasion (arrowheads) by early adenocarcinoma lacks MME expression in PtenPE−/− mice. The ABC Elite method with hematoxylin counterstaining was performed. Scale bar, 60 and 30 µm (insets). Immunostainings are representative of six WT and six PtenPE−/− mice, respectively.

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