Fig. 6: Scheme of the SOX9-FOXC1 model in TNBC.

SOX9 activates FOXC1 transcription by binding its enhancers. Then, SOX9 and FOXC1 collaborate to activate an oncogenic gene regulatory program. THZ1 can inhibit the binding of SOX9 on enhancers near FOXC1 by inhibiting CDK7.