Fig. 6: TRIM3 promotes transcription of ER-target genes in clinical breast cancer.

Western blotting of TRIM3 and ESR1 (A), qPCR of ER-targeted genes (B) in 10 cases of freshly ER⁺ breast cancer treated with tamoxifen therapy, including tamoxifen-resistant and tamoxifen-sensitive tissues. GAPDH was used as the loading control. A star represents SUMOylation of ESR1.