Fig. 4: RNA-seq analysis of MLS 402-91 cells upon RNAi-mediated silencing of FUS-DDIT3 and YAP1. | Oncogenesis

Fig. 4: RNA-seq analysis of MLS 402-91 cells upon RNAi-mediated silencing of FUS-DDIT3 and YAP1.

From: Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma

Fig. 4

A GSEA plots illustrate top depleted ‘Hallmark’ gene sets shared by the siDDIT3 and siYAP1 conditions, showing downregulation of MYC and E2F targets in MLS 402-91 cells. B Significantly enriched gene sets co-regulated by FUS-DDIT3 and YAP1 are associated with apoptosis and p53 pathways. The normalized enrichment score, nominal P value and false discovery rate q-value are shown. C In total, 1867 differentially expressed genes were significantly downregulated in the siDDIT3 condition, 2816 genes were downregulated in the siYAP1 condition, and the overlap of both conditions comprised 503 genes. D The set of shared upregulated genes between the siDDIT3 (n = 2129) and siYAP1 (n = 2811) samples comprised 702 genes. E, F Enrichr analysis of siDDIT3- and siYAP1-co-regulated genes showing the top down- and upregulated pathways derived from MSigDB Hallmark 2020.

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