Fig. 8: Clinical relevance of the levels of p53, DNMT1, GDF15, and CCL5 in lung cancer cohorts. | Oncogenesis

Fig. 8: Clinical relevance of the levels of p53, DNMT1, GDF15, and CCL5 in lung cancer cohorts.

From: Estradiol-mediated inhibition of DNMT1 decreases p53 expression to induce M2-macrophage polarization in lung cancer progression

Fig. 8: Clinical relevance of the levels of p53, DNMT1, GDF15, and CCL5 in lung cancer cohorts.

The ten clinical specimens were collected from early-stage lung cancer patients used to study the association among the levels of p53, DNMT1, GDF15, and CCL5 by IHC staining (A, a), and the results were scored from 0 to 3 according to the IHC signal (A, b). The working model of the role of estradiol in lung cancer malignancy is shown (B).

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