Fig. 1: RB-loss correlates with reduced expression of immune hallmarks and increased RNA expression of CD274 and PVR in mouse and human breast cancer. | Oncogenesis

Fig. 1: RB-loss correlates with reduced expression of immune hallmarks and increased RNA expression of CD274 and PVR in mouse and human breast cancer.

From: CDK4/6 inhibitors and the pRB-E2F1 axis suppress PVR and PD-L1 expression in triple-negative breast cancer

Fig. 1

A GSEA comparing immune-related pathways in RbΔp53Δ (red) with p53Δ (blue) TNBC-like mammary tumors, visualized by Cytoscape. NES normalized enrichment score. B Correlation analysis of immune markers (right labels) with molecular signatures (bottom labels) in patient samples of 1302 mixed breast cancer and 205 TNBC. C Correlation level of CD274 (PD-L1) and PVR with indicated RB-related pathways. D Summary of ENCODE analysis for the PVR and CD274 promoter region (see Supplementary Fig. S3A). *P < 0.05, **P < 0.001, ***P < 0.0001, &P = 0.0659.

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