Fig. 3: Identification of CSC-enriched subpopulations. | Oncogenesis

Fig. 3: Identification of CSC-enriched subpopulations.

From: Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Fig. 3

A UMAP projection of BER-DSRCT and JN-DSRCT-1 cells in adherent (A) or sphere (S) culture divided into 11 clusters. B Expression of the sphere-enriched signature (top row) and adherent-enriched signature (bottom row) in single cells. C UMAP projection of DSRCT single cells labeled by cell cycle phase. D Venn diagram of enriched pathways in clusters 1, 7, 5, and 9. E GSEA of DNA Binding Transcription Activator Activity gene set on clusters 1 and 7. F GSEA of Mitotic Cell Cycle Process gene set on clusters 5 and 9. G GSEA of Chromatin, Neurogenesis, and Kinase Binding gene sets on cluster 7. H GSEA of Endopeptidase Regulatory Activity gene set on cluster 1.

Back to article page