Fig. 7: Schematic diagram illustrating the cooperation between MYCN and KAT2A.

MYCN directly activates KAT2A transcription, while KAT2A acetylates and stabilizes MYCN protein. MYCN recruits KAT2A to activate its targets and targeting KAT2A through PROTAC degrader antagonizes MYCN-mediated gene transcription regulation (Created with BioRender.com).