Fig. 4: SRCAP-1879 truncation promotes gene expression changes driving cancer.
From: A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression
A Volcano plot of differentially expressed genes and B associated GO terms in the mutant progenitor state. C Volcano plot of differentially expressed genes and D associated GO terms in the mutant progenitor state. E Diagram of the Epidermal Differentiation Complex and heatmap of gene expression changes at the Epidermal Differentiation Complex. F Heatmap of gene expression changes of proliferation genes. G Heatmap of gene expression changes of EMT markers. H Heatmap of gene expression changes affecting integrins and MMPs. All heatmaps show the log2 fold change UD 1879 relative to UD control on top and the log2 fold change DF 1879 relative to DF control on bottom.
