Fig. 7: A working model for crosstalk between SHH and CMKLR1 pathways in MB pathogenesis.
From: CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis
The Sonic Hedgehog pathway triggers chemerin/CMKLR1 signaling through transcriptional activation of CMKLR1 and repression of RGS16. Chemerin/CMKLR1 promotes the malignant behaviors of MB cells via Gi and PI3K/Akt pathway. Meanwhile, the activated Gi further expedites Hedgehog signaling through repression of PKA and thereby reduced phosphorylation of Gli2. Thus, the SHH/Gli and CMKLR1 pathways form a regulatory circuit to collaboratively orchestrate MB development.
