Abstract
Background
To evaluate the efficacy of stoss therapy using fortified biscuit for vitamin D-deficient children.
Methods
A total of 108 children aged 30–72 months with vitamin D deficiency were studied in a randomized single-blind clinical trial. The deficient children were assigned to three groups, namely, vitamin D-fortified biscuit (BG), capsule vitamin D (CG), and ampoule vitamin D (AG). Capsules and biscuits containing 50,000 IU of cholecalciferol were consumed twice per week for 3 consecutive weeks. Ampoules with 300,000 IU of cholecalciferol were injected intramuscularly in a single dose. Three weeks after treatment, serum 25(OH)D concentrations were measured, and the three groups were compared.
Results
Each method of treatment could increase the mean serum 25(OH)D concentration to optimal level. Serum 25(OH)D concentrations ≥100 ng/mL were observed in six children, including four from AG and two from CG (P = 0.09). The comparison of the mean serum 25(OH)D concentrations after treatment showed between ampoule and capsule (P = 0.3) and capsule and biscuit (P = 0.62) were insignificant; however, the ampoule and biscuit groups differed significantly (P = 0.012).
Conclusion
Stoss therapy using fortified biscuit may be an effective way to improve compliance in children who cannot take capsules without adverse effects and may also be recommended for prevention purposes.
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Acknowledgements
Hereby, we wish to express our gratitude to the children and their families for participating in this study and the staff at the Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences.
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Moslemi, L., Esmaeili dooki, M., Moghadamnia, A.A. et al. Stoss therapy using fortified biscuit for vitamin D-deficient children: a novel treatment. Pediatr Res 84, 662–667 (2018). https://doi.org/10.1038/s41390-018-0135-4
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DOI: https://doi.org/10.1038/s41390-018-0135-4
