Table 3 Secondary outcome measures of school-age children

From: Recommendations for the design of therapeutic trials for neonatal seizures

Criteria

Description

Post-neonatal onset epilepsy

Specify seizure type according to ILAE77,78

Neuromotor outcomes

1. Gross Motor Function Classification System (GMFCS)

2. Gross Motor Function Measure (GMFM)

3. Movement Assessment Battery for Children (Movement ABC 2)93: 4 to 12 years; targeted to detect gross motor or fine motor impairments

4. Peabody Developmental Motor Scale, revised (PDMS-2)94

Cognitive outcomes

1. British Ability Scale, Third Edition (BAS 3)95: 3 years to 17 years 11 months; Early Years Battery for 3 years to 5 years 11 months

2. Differential Ability Scales Second Edition (DAS-II)96: 3 years 6 months to 17 years

3. Mullen Scale of Early Learning: Birth to 5 years 8 months

4. Stanford-Binet Intelligence Scales, Fifth Edition (SB5)97: 2 years to 85 years

  a. Wechsler Preschool and Primary Scale of Intelligence—Fourth Edition (WPPSI—IV)98: 2 years 6 months to 7 years 7 months

  b. Wechsler Intelligence Scale for Children—Fifth Edition (WISC—V)99: 6 years to 16 years 11 months

5. Standardized tests of executive function, which underpin many adverse cognitive outcomes

  a. NEPSY, Second Edition (NEPSY-II)100

  b. Behavior Rating Index of Executive Function, Second Edition (BRIEF2)101

  c. Cognitive Assessment System, Second Edition102

6. Behavior and social-emotional problems: many questionnaires/surveys are available for this age group, including the Child Behavior Checklist103, BITSEA104, ITSEA104, and M-CHAT105

7. Academic attainment tests are for school-age children, 6 years and above