Fig. 2 | Pediatric Research

Fig. 2

From: Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion

Fig. 2

Fibrinogen binding to resting and activated platelets from neonates born at different gestational ages. Platelets from 28 neonates were activated with ADP a–c or CRP-XL d–f and fibrinogen binding was measured by flow cytometry. Neonates were divided according to their gestational age and mean dose response curves (mean ± SEM) are shown using either ADP (a) or CRP-XL (d) as an agonist. Platelet response to ADPmax (10 µM) (b) or CRP-XLmax (10 µg/mL) (e) are shown (mean ± SEM). The EC50 values were calculated from baseline removed, normalize, non-linear regression curves (c, f, mean ± 95% confidence interval)

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