Abstract
Backgrounds
Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.
Methods
A case–control study with 1092 Chinese children was conducted.
Results
We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (Pinteraction = 0.027), and rs12487736 was associated with SBP in the subgroup having high calorie foods at least once in the last week (b = 2.19, P = 0.025), but not in the subgroup not having high calorie foods. Also, interaction between protein intake (meat/fish/soy beans/egg) and rs12487736 on diastolic BP (DBP) was identified (Pinteraction = 0.049); rs12487736 was associated with DBP in the subgroup consuming protein (meat/fish/soy beans/egg) <twice/day (b = 3.38, P = 0.014), but not in the subgroup ≥twice/day. There is combined effect between rs12487736 and physical activity on DBP. In the subgroup who were inactive (physical activity <1 h/day), rs12487736 was significantly associated with DBP (b = 3.27, P = 0.046), but not in the active group (physical activity ≥1 h/day). Similar combined effect between rs12487736 and soft drink was found.
Conclusions
Interactions or combined effects between SCAP and lifestyle behaviors on BP support the importance of promoting a healthy lifestyle in the children genetically predisposed to higher BP.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
GBD 2016 Risk Factors Collaborator. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England) 390, 1345–1422 (2017).
Chen, X. & Wang, Y. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 117, 3171–3180 (2008).
Chu, C. et al. Associations of risk factors in childhood with arterial stiffness 26 years later: the Hanzhong adolescent hypertension cohort. J. Hypertens. 35(Suppl. 1), S10–s5 (2017).
Munoz, M. et al. Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank. Nat. Genet. 48, 980–983 (2016).
Poulter, N. R., Prabhakaran, D. & Caulfield, M. Hypertension. Lancet (Lond., Engl.). 386, 801–812 (2015).
Brown, M. S. & Goldstein, J. L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl Acad. Sci. USA 96, 11041–11048 (1999).
Liu, F. H. et al. The gene–gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children. BioMed. Res. Int. 2014, 538564 (2014).
Durst, R. et al. The discrete and combined effect of SREBP-2 and SCAP isoforms in the control of plasma lipids among familial hypercholesterolaemia patients. Atherosclerosis 189, 443–450 (2006).
Fan, Y. M. et al. Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death. Thromb. J. 6, 17 (2008).
Yang, Y. D. et al. Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children. PLoS ONE 12, e0177973 (2017).
Meng, X. R. et al. Association study of childhood obesity with eight genetic variants recently identified by genome-wide association studies. Pediatr. Res. 76, 310–315 (2014).
Wang, S. et al. Physical activity and sedentary behavior can modulate the effect of the PNPLA3 variant on childhood NAFLD: a case-control study in a Chinese population. BMC Med. Genet. 17, 90 (2016).
Song, J. Y., Song, Q. Y., Wang, S., Ma, J. & Wang, H. J. Physical activity and sedentary behaviors modify the association between melanocortin 4 receptor gene variant and obesity in chinese children and adolescents. PLoS ONE 12, e0170062 (2017).
Wang, D. et al. Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals. Obesity (Silver Spring, MD) 18, 573–579 (2010).
Wang, H. J., Zhang, H., Zhang, S. W., Pan, Y. P. & Ma, J. Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents. Biomed. Environ. Sci. 21, 528–536 (2008).
Jie, M. I. et al. Development of blood pressure reference standards for Chinese children and adolescents. Chinese. J. Evid. Based Pediatr. 5, 4–14 (2010).
The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114, 555–576 (2004).
Chen, C. Prevention and Control Guidelines of Overweight and Obesity for Chinese School Children and Adolescents 1st edn (People’s Medical Publishing House, Beijng, 2008).
American Academy of Pediatrics. American Academy of Pediatrics: Children, adolescents, and television. Pediatrics 107, 423–426 (2001).
Dempfle, A. et al. Gene–environment interactions for complex traits: definitions, methodological requirements and challenges. Eur. J. Hum. Genet. 16, 1164–1172 (2008).
Qi, Q. et al. Fried food consumption, genetic risk, and body mass index: gene–diet interaction analysis in three US cohort studies. BMJ (Clin. Res. Ed.) 348, g1610– (2014).
Ma, Y. & Ordovas, J. M. The integration of epigenetics and genetics in nutrition research for CVD risk factors. Proc. Nutr. Soc. 76, 333–346 (2017).
Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L. & Brown, M. S. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276, 4365–4372 (2001).
Calder, P. C. Functional roles of fatty acids and their effects on human health. J. Parent. Enter. Nutr. 39, 18S–32S (2015).
Kalantarian, S., Rimm, E. B., Herrington, D. M. & Mozaffarian, D. Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women. Am. Heart J. 167, 627–35.e1 (2014).
Guan, D. et al. Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes. Cell 174, 831–42 e12 (2018).
Zou, Z. Y. et al. The importance of blood lipids in the association between BMI and blood pressure among Chinese overweight and obese children. Br. J. Nutr. 116, 45–51 (2016).
Daily, J. W. & Park, S. Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults. Nutrition (Burbank, Los Angel. Cty., Calif.). 33, 187–194 (2017).
Mastrocola, R. et al. Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice. Am. J. Physiol. Gastrointest. Liver Physiol. 305, G398–G407 (2013).
Li, Y., Wei, F. F., Wang, S., Cheng, Y. B. & Wang, J. G. Cardiovascular risks associated with diastolic blood pressure and isolated diastolic hypertension. Curr. Hypertens. Rep. 16, 489 (2014).
Franklin, S. S. et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation 103, 1245–1249 (2001).
Popkin, B. M., Lu, B. & Zhai, F. Understanding the nutrition transition: measuring rapid dietary changes in transitional countries. Public Health Nutr. 5, 947–953 (2002).
Acknowledgements
This study was supported by Grants from National Natural Science Foundation of China (81573170, H.-J.W., http://www.nsfc.gov.cn/), National Natural Science Foundation of China (81673192, J.M., http://www.nsfc.gov.cn/), Hunan Provincial Natural Science Foundation of China (2019JJ50376, Y.-D.Y.) and a project supported by Scientific Research Fund of Hunan Provincial Education Department (18C0072, Y.-D.Y.).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
About this article
Cite this article
Yang, YD., Song, JY., Wang, S. et al. Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children. Pediatr Res 86, 389–395 (2019). https://doi.org/10.1038/s41390-019-0402-z
Received:
Revised:
Accepted:
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41390-019-0402-z
This article is cited by
-
Association of BMAL1 clock gene polymorphisms with fasting glucose in children
Pediatric Research (2023)
